Title:
METHODS FOR LIGAND DISCOVERY
Document Type and Number:
Japanese Patent JP2013116121
Kind Code:
A
Abstract:
To discover ligands using combined technique.
There are provided new methods for ligand discovery. The inventive methods rely on a process termed "tethering" where potential ligands are covalently bonded or "tethered" to a target and subsequently identified. In one embodiment, the invention concerns a target-compound conjugate. In a particular embodiment, the target is selected from the group consisting of enzymes, receptors, transcription factors, ligands for receptors, growth factors, cytokines, immunoglobulins, nuclear proteins, signal transduction components, and allosteric enzyme regulators.
Inventors:
ERLANSON DANIEL A
BRAISTED ANDREW A
WELLS JAMES
BRAISTED ANDREW A
WELLS JAMES
Application Number:
JP2013031749A
Publication Date:
June 13, 2013
Filing Date:
February 21, 2013
Export Citation:
Assignee:
SUNESIS PHARMACEUTICALS INC
International Classes:
C12Q1/00; G01N33/531; B01D59/44; C07C323/39; C07C335/04; C07D207/46; C07D333/38; C07D333/70; C07D401/04; C07D405/12; C07K14/00; C07K14/435; C07K14/47; C12N9/00; C12Q1/68; C12Q1/70; C40B20/08; C40B30/04; C40B40/04; G01N33/00; G01N33/15; G01N33/50; G01N33/53; G01N33/543; H01J49/00; C07B61/00
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita