Title:
腫瘍細胞の成長を阻害するための方法および製薬学的組成物
Document Type and Number:
Japanese Patent JP4549443
Kind Code:
B2
Abstract:
Method of treating or inhibiting proliferation of a peroxisome proliferator-activated receptor (PPAR) gamma -responsive cell, comprising contacting the cell with a PPARgamma agonist. Also claimed is a composition comprising: (a) a PPARgamma ligand to induce terminal differentiation of a PPARgamma -responsive hyperproliferative cells in animals; (b) at least one agent selected from mitotic inhibitors, alkylating agents, antimetabolites, nucleic acid intercalating agents, topoisomerase inhibitors, agents which promote apoptosis and agents which increase immune responses to tumours; and (c) a carrier.
Inventors:
Bruce M. Spiegelman
Arteio, sonar
Elizabethta, Miura
Sarah, Pashiya
Peter Tontnoz
Arteio, sonar
Elizabethta, Miura
Sarah, Pashiya
Peter Tontnoz
Application Number:
JP52700198A
Publication Date:
September 22, 2010
Filing Date:
December 11, 1997
Export Citation:
Assignee:
Dana-Farber Cancer Institute, Inc.
International Classes:
A61K31/421; C07D291/04; A61K31/422; A61K31/425; A61K31/426; A61K31/427; A61K31/433; A61K31/4439; A61K45/00; A61K45/06; A61P35/00; A61P35/02; C07D263/56; C07D285/12; C07D413/14; C07D417/06; C07D417/12
Foreign References:
| WO1996034943A1 | ||||
| WO1996033724A1 | ||||
| WO1993021146A1 | ||||
| WO1995010271A1 | ||||
| WO1997010819A1 |
Other References:
LAMBE, K.G., et al., Eur. J. Biochem., 239(1), pp.1-7 (1996)
河野 通明, 薬学研究の進歩(平成7年度版), 薬学研究奨励財団研究成果報告集12, pp.1-15 (1996)
TONTONOZ, P., et al., Proc. Natl. Acad. Sci. USA, 94, pp.237-241 (1997)
ZHANG, B., et al., J. Biol. Chem., 271(50), pp.31771-31774 (1996)
河野 通明, 薬学研究の進歩(平成7年度版), 薬学研究奨励財団研究成果報告集12, pp.1-15 (1996)
TONTONOZ, P., et al., Proc. Natl. Acad. Sci. USA, 94, pp.237-241 (1997)
ZHANG, B., et al., J. Biol. Chem., 271(50), pp.31771-31774 (1996)
Attorney, Agent or Firm:
Mizuno Yuuki