Title:
エスシタロプラムを含む微粒球状徐放出注射剤及びその製造方法
Document Type and Number:
Japanese Patent JP7266220
Kind Code:
B2
Abstract:
The present invention relates to a biodegradable polymer microsphere-containing sustained-release injection containing escitalopram as an active ingredient, and to a method for manufacturing the same. In the case of escitalopram microspheres, there is a problem of low encapsulation rate, fracture due to weak strength, and initial over-release due to the phase separation of the liquid drug and the polymer inside the microspheres. In order to solve the problem, it is possible to maximize the encapsulation amount and the encapsulation efficiency of the escitalopram adding a hydrophobic solidifying agent to uniformize the non-uniform phase, to overcome the cracking of the microspheres at high loading conditions, and to properly control the initial release and release delay of the microspheres.
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Inventors:
Shin, Byun Cheol
Cho, Song Han
Yang, Tae Kyung
Kang, Seok Hee
Park, Eun Hee
Cho, Song Han
Yang, Tae Kyung
Kang, Seok Hee
Park, Eun Hee
Application Number:
JP2020543445A
Publication Date:
April 28, 2023
Filing Date:
November 01, 2018
Export Citation:
Assignee:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Korea Pharma Company, Limited
Korea Pharma Company, Limited
International Classes:
A61K31/343; A61K9/107; A61K47/12; A61K47/34; A61K47/36; A61P25/24
Domestic Patent References:
| JP2007500238A | ||||
| JP2003206240A | ||||
| JP2013543874A | ||||
| JP2016515612A |
Other References:
T.G.Yang et al.,Suppression of initial burst in PLGA Microspheres using polymeric complex,The Polymer Society of Korea 2017 Fall Conference Research Thesis,2017年,Vol.42,p.90,Retrieved from the Internet:
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK