パントラクトンおよびパントテン酸誘導体を含むアシル補酵素-Aのミミック、その組成物、ならびにコレステロール管理の方法および関連の使用

Title:

パントラクトンおよびパントテン酸誘導体を含むアシル補酵素-Aのミミック、その組成物、ならびにコレステロール管理の方法および関連の使用

Document Type and Number:

Japanese Patent JP2005522504

Kind Code:

A

Abstract:

The invention relates to novel Acyl coenzyme-A mimics, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The Acyl coenzyme-A mimics, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, bacterial infection and impotence. In certain embodiments, the Acyl coenzyme-A mimics, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

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Inventors:

Dassault, Jean-Louis
Onishiu, Carmen, Daniela

Application Number:

JP2003583996A

Publication Date:

July 28, 2005

Filing Date:

April 10, 2003

Export Citation:

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Assignee:

Esperion Therapeutics, Incorporated

International Classes:

A61K31/6615; A61K9/08; A61K9/20; A61K31/075; A61K31/10; A61K31/12; A61K31/121; A61K31/13; A61K31/133; A61K31/16; A61K31/164; A61K31/23; A61K31/27; A61K31/351; A61K31/4406; A61K31/66; A61K31/683; A61P1/18; A61P3/04; A61P3/06; A61P3/08; A61P3/10; A61P7/02; A61P9/00; A61P9/12; A61P13/12; A61P15/10; A61P25/28; A61P29/00; A61P31/04; A61P35/00; A61P43/00; C07C45/45; C07C49/17; C07C49/172; C07C59/347; C07C59/353; C07C69/675; C07C69/757; C07C215/08; C07C215/12; C07C235/08; C07C235/10; C07C235/16; C07C237/22; C07C239/12; C07C239/22; C07C271/16; C07D213/40; C07D309/10; C07D309/12; C07F9/09; C07F9/655; C12N9/00; C12Q1/25; (IPC1-7): C07C235/10; A61K9/08; A61K9/20; A61K31/16; A61K31/164; A61K31/351; A61K31/4406; A61P1/18; A61P3/04; A61P3/06; A61P3/08; A61P7/02; A61P9/00; A61P9/12; A61P13/12; A61P15/10; A61P25/28; A61P29/00; A61P31/04; A61P35/00; A61P43/00; C07C235/16; C07C237/22; C07D213/40; C07D309/10; C12Q1/25

Attorney, Agent or Firm:

Yusuke Hiraki
Ishii Teiji
Satoshi Fujita

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