Title:
改変アデノウイルス及びこれを含む医薬
Document Type and Number:
Japanese Patent JP7406263
Kind Code:
B2
Abstract:
[Problem] The purpose of the present invention is to provide a modified adenovirus having a cytocidal activity on a target cell and high safety. [Solution] The present invention pertains to: a modified adenovirus which comprises an E1A gene, an enhancer sequence having a function of enhancing the expression of the E1A gene, and an AU-rich element introduced into the 3'-untranslated region of a viral gene, which is essentially required for the self-propagation thereof, or a position adjacent to the 3'-untranslated region, or a modified adenovirus which comprises an E1A gene and an enhancer sequence having a function of enhancing the expression of the E1A gene and cannot express normal E4orf6 protein, wherein the distance between the 5'-terminus of the E1A gene and the terminus of the enhancer sequence is 1500-4500 bp; and a medicine comprising the same.
Inventors:
Fumihiro Higashino
Application Number:
JP2021507412A
Publication Date:
December 27, 2023
Filing Date:
March 19, 2020
Export Citation:
Assignee:
National University Corporation Hokkaido University
International Classes:
C12N15/34; A61K35/761; A61K48/00; A61P29/00; A61P35/00; C12N7/01
Domestic Patent References:
| JP2016160249A | ||||
| JP2002525063A |
Foreign References:
| US20130302313 |
Other References:
ELOIT M. et al.,Isogenic adenoviruses type 5 expressing or not expressing the E1A gene: efficiency as virus vectors in the vaccination of permissive and non-permissive species,Journal of General Virology,1995年,vol.76,p.1583-1589
HEARING P. et al.,The adenovirus type 5 E1A enhancer contains two functionally distinct domains: one is specific for E1A and the other modulates all early units in Cis,Cell,1986年,vol.45,p.229-236
MIKAWA Y. et al.,Conditionally replicative adenovirus controlled by the stabilization system of AU-rich elements containing mRNA,Cancers,2020年05月11日,vol.12,e.1205
HALBERT D. N. et al.,Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff,Journal of Virology,1985年,vol.56, no.1,p.250-257
HEARING P. et al.,The adenovirus type 5 E1A enhancer contains two functionally distinct domains: one is specific for E1A and the other modulates all early units in Cis,Cell,1986年,vol.45,p.229-236
MIKAWA Y. et al.,Conditionally replicative adenovirus controlled by the stabilization system of AU-rich elements containing mRNA,Cancers,2020年05月11日,vol.12,e.1205
HALBERT D. N. et al.,Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff,Journal of Virology,1985年,vol.56, no.1,p.250-257
Attorney, Agent or Firm:
Patent Attorney Corporation IP Assist
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