N-((3,6-DISUBSTITUTED)PHENYL)UREA AND CARBONATE INHIBITOR OF ACYL COENZYME A:CHOLESTEROL TRANSFERASE

Title:

N-((3,6-DISUBSTITUTED)PHENYL)UREA AND CARBONATE INHIBITOR OF ACYL COENZYME A:CHOLESTEROL TRANSFERASE

Document Type and Number:

Japanese Patent JPH0193569

Kind Code:

A

Abstract:

NEW MATERIAL: A compd. of formula I [R1, R2 are each a 1 to 6C alkyl, F, Cl, Br, OR3 (R3 is a 1 to 6C alkyl, phenylmethyl); X is S, O; Y is O, NH; R4, R5 are each H, a 1 to 6C alkyl, or form a satd. carbon cyclic ring together with bonded C; A is a 6 to 17C, straight or branched alkyl which may have a double bond].

EXAMPLE: N-[2-Ethyl-6-(1-methylethyl)phenyl]-N'-tetradecyl urea.

USE: A cholesterol absorption regulator.

PROCESS: The compd. of formula I is obtd. b bringing a compd. of formula II and a compd. of formula III into reception at room temp. in a polar nonprotonic org. solvent (e.g.; ethyl acetate).

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Inventors:

UIRIAMU HAWAADO ROOKU
BURUUSU DEIBITSUDO ROSU
BARATO KARIDASU TORIBEDEI

Application Number:

JP16274488A

Publication Date:

April 12, 1989

Filing Date:

July 01, 1988

Export Citation:

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Assignee:

WARNER LAMBERT CO

International Classes:

A61K31/17; A61K31/27; A61P3/06; A61P43/00; C07C67/00; C07C239/00; C07C271/38; C07C271/28; C07C275/24; C07C275/28; C07C275/30; C07C325/00; C07C333/08; C07C335/16; C07C335/18; C12N9/99; (IPC1-7): A61K31/17; A61K31/27; C07C125/065; C07C127/19; C07C155/02; C07C157/09; C12N9/99

Attorney, Agent or Firm:

Chika Takagi (2 outside)

Next Patent: SYNTHESIS OF VITAMIN A AND ITS DERIVATIVE