選択的モノアミンオキシダーゼBインヒビターとしてのN-アシルアミノベンゼン誘導体

Japanese Patent JP4223003

B2

This invention relates to N-acylamino aryl derivatives of the formula where R¹, R²¹, R²², R²³, R²⁴, R³, R⁴, R⁵, R⁶, R⁷, R⁸, R, and n are as defined herein and where X is -CHRO, -OCHR-, -CH₂S-, -SCH₂-, -CH₂CH₂-, -CH-CH- or -C≡C-. The compounds of the invention are selective monoamine oxidase B inhibitors, and they are therefore useful in the treatment of diseases mediated by monoamine oxidase B, for example, for the treatment of Alzheimer's disease or senile dementia.

Yoridon, Genese
Rodriguez Sarmiento, Rosa Maria
Thomas, Andrew William
Wyler, Rene

JP2004507421A

February 12, 2009

May 20, 2003

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F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT

A61P3/00; C07C233/15; A61K31/15; A61K31/167; A61K31/216; A61K31/275; A61P3/04; A61P25/00; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P25/34; A61P29/00; A61P43/00; C07C231/02; C07C233/25; C07C233/33; C07C233/60; C07C235/16; C07C237/04; C07C237/22; C07C243/14; C07C243/28; C07C255/19; C07C255/23; C07C255/25; C07C255/58; C07C259/06; C07C323/41

EP0632017A1
DE1003753A

Acta Facultatis Pharmaceuticae Bohemoslovenicae,1966年,12,p.189-202
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第4版 実験化学講座22 有機合成IV -酸・アミノ酸・ペプチド-,丸善株式会社,1992年11月30日,p.138-144,「a.カルボン酸とアミンまたはアンモニアからの合成」の項

Hajime Tsukuni
Fumio Shinoda

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