N-CONTAINING HETEROCYCLIC COMPOUND - YM BIOSCIENCES AUSTRALIA PTY

Title:

N-CONTAINING HETEROCYCLIC COMPOUND

Document Type and Number:

Japanese Patent JP2016006113

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To design and/or identify compounds which specifically inhibit kinases of JAK and Aurora family, especially compounds which may preferentially inhibit one or more of JAK kinases compared with other JAK kinases.SOLUTION: The invention relates to an N-containing heterocyclic compound which is an inhibitor of protein kinases including JAK kinases. More specifically, the compounds are selective to JAK1, JAK2, JAK3 or TYK2 kinases and combinations thereof (for example, a combination of JAK1 and JAK2 and the like). These kinase inhibitors can be used for treatments of kinase related diseases, for example immunological and inflammatory diseases including organ transplantation; hyperproliferative diseases including cancer and myeloproliferative diseases; virus diseases; metabolic diseases; and vascular diseases and the like.

Inventors:

DAVID GERARD BOURKE
BURNS CHRISTOPHER JOHN
ANTHONY NICHOLAS CUZZUPE
JOHN THOMAS FEUTRILL
MARCEL ROBERT KLING
TRACY LEAH NERO

Application Number:

JP2015171850A

Publication Date:

January 14, 2016

Filing Date:

September 01, 2015

Export Citation:

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Assignee:

YM BIOSCIENCES AUSTRALIA PTY

International Classes:

C07D487/04; A61K31/519; A61K31/5377; A61P3/00; A61P9/00; A61P29/00; A61P31/12; A61P35/00; A61P37/02; A61P43/00; C07D495/04

Domestic Patent References:

JP2005523251A	2005-08-04
JP2005523251A	2005-08-04

Foreign References:

WO2003055890A1	2003-07-10
US20070142402A1	2007-06-21
WO2003055890A1	2003-07-10
US20070142402A1	2007-06-21

Attorney, Agent or Firm:

Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe

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