N-TERMINUS MODIFIED ANALOG OF LHRH

Title:

N-TERMINUS MODIFIED ANALOG OF LHRH

Document Type and Number:

Japanese Patent JP2005170950

Kind Code:

A

Abstract:

To provide a medicine inhibiting activity of luteinizing hormone releasing hormone (LHRH) as a remedy for sex steroid much related diseases.

Decapeptides and undecapeptides substituted on the N-terminal nitrogen atom by acyl groups (which include furo-2-yl, isonicotinyl, nicotinyl, 2-quinolinecarbonyl, 3-quinolinecarbonyl, and 4-quinolinecarbonyl, shikimyl, dihydroshikimyl and tetrahydrofur-2-oyl) are potent antagonists of LHRH. The antagonists of LHRH are useful for suppressing the levels of sex hormones in mammals.

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Inventors:

HAVIV FORTUNA
FITZPATRICK TIMOTHY D
SWENSON ROLF E
NICHOLS CHARLES J
MORT NICHOLAS A

Application Number:

JP2004378980A

Publication Date:

June 30, 2005

Filing Date:

December 28, 2004

Export Citation:

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Assignee:

TAP HOLDINGS INC

International Classes:

A61K38/00; A61P5/04; A61P5/12; A61P5/28; A61P5/32; A61P13/02; A61P13/08; A61P15/00; A61P15/08; A61P15/18; A61P25/04; A61P35/00; C07K7/06; C07K7/08; C07K7/23; (IPC1-7): C07K7/06; A61K38/00; A61P5/04; A61P5/28; A61P5/32; A61P13/08; A61P15/00; A61P15/08; A61P15/18; A61P35/00; C07K7/08

Attorney, Agent or Firm:

Yoshio Kawaguchi

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