PURPOSE: To provide the subject pharmaceutical containing hardly absorbable physiologically active substance(s), low in irritancy to the mucous membrane and the skin, comprising a combination of each specific plural surfactants.

CONSTITUTION: The objective pharmaceutical comprises a combination of (A) an ionic surfactant such as sodium di-2-ethylhexylsulfosuccinate, (B) a nonionic surfactant 10-20 in HLB number such as polyoxyethylene (hardened) castor oil (pref. 40-60 in the average number of moles of oxyethylene added) and (C) a second nonionic surfactant 3-7 in HLB number such as a mono- or polyglycerin fatty acid ester (pref., said fatty acid being 18C (saturated) fatty acid; 1-2 in the number of moles of the fatty acid added per mole of glycerin; 0-4 in the number of moles of glycerin added) with the component C as the essential component. In this pharmaceutical, its aqueous phase contains such physiologically active substance(s) as to be low in percutaneous/permucosal absorbability such as vasopressin.