Title:
新規な環状テトラペプチド誘導体とその医薬用途
Document Type and Number:
Japanese Patent JP4269041
Kind Code:
B2
Abstract:
The present invention provides a cyclic tetrapeptide derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof: wherein each of R21 and R22 independently denotes hydrogen, a linear C1-C6-alkyl group to which a non-aromatic cycloalkyl group or an optionally substituted aromatic ring may be attached, or a branched C3-C6-alkyl group to which a non-aromatic cycloalkyl group or an optionally substituted aromatic ring may be attached; and each of R1 and R3 independently denotes a linear C1-C5-alkylene group which may have a C1-C6 side chain, in which the side chain may form a condensed ring structure on the alkylene chain. The present invention also provides a histone deacetylase inhibitor, an MHC class-I molecule expression-promoting agent and a pharmaceutical composition, each of which comprises the above cyclic tetrapeptide derivative or pharmaceutically acceptable salt thereof as an active ingredient.
Inventors:
Norikazu Nishino
Minoru Yoshida
Horinouchi Sueji
Yasuhiko Komatsu
Minoru Yoshida
Horinouchi Sueji
Yasuhiko Komatsu
Application Number:
JP5385199A
Publication Date:
May 27, 2009
Filing Date:
March 02, 1999
Export Citation:
Assignee:
Kyushu Institute of Technology
International Classes:
C07K5/12; A61K31/00; C12N9/99; A61K38/00; A61P35/00
Foreign References:
| WO1999011659A1 |
Other References:
Peptides(1998)p.832-833
Peptide Science,Vol.35(1998)p.181-184
Peptide Science,Vol.35(1998)p.185-188
Peptide Science,Vol.35(1998)p.189-192
Peptide Science,Vol.35(1998)p.181-184
Peptide Science,Vol.35(1998)p.185-188
Peptide Science,Vol.35(1998)p.189-192
Attorney, Agent or Firm:
Maeda Junhiro
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