Title:
2‘水酸基を修飾された新規人工RNA
Document Type and Number:
Japanese Patent JP4805143
Kind Code:
B2
Abstract:
The purpose of the present invention is to develop a system for efficiently constituting cyanoethyl ethers under mild conditions and probability of the ethers as functional groups for imparting specific functions and to make a contribution to the production of novel functional nucleic acids. The present invention relates to a nucleoside that is represented by the general formula (I) or a nucleotide derived therefrom:
wherein X and Y may be the same as or different from each other, and are hydrogen, optionally substituted silyl group, 4-methoxytrityl group, 4,4'-dimethoxytrityl group or a group represented by the general formula (II):
wherein R1 and R2 may be the same as or different from each other, representing an alkyl group having 1-7 carbon atoms such as diisopropyl, or they are united with each other to form a ring structure, R3 represents a protective group for a phosphoric acid such as 2-cyanoethyl; and B1 represents an optionally substituted pyrimidine or purine base.
Inventors:
Mitsuo Sekine
Yasushi Kiyoo
Naoyoshi Michiyoshi
Yasushi Kiyoo
Naoyoshi Michiyoshi
Application Number:
JP2006510680A
Publication Date:
November 02, 2011
Filing Date:
March 02, 2005
Export Citation:
Assignee:
Japan Science and Technology Agency
International Classes:
C07H19/067; C07H19/167; C07H21/02; C07H23/00; C07F7/18; C07F9/6558; C07F9/6561
Foreign References:
| WO2002020546A1 | 2002-03-14 |
Attorney, Agent or Firm:
Masahiro Abe
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