Title:
NEW FKI-1746-1 AND FKI-1746-2 SUBSTANCES AND METHOD FOR PRODUCING THE SUBSTANCES
Document Type and Number:
Japanese Patent JP2009184946
Kind Code:
A
Abstract:
To provide new substances having a macrophage intrafat drop accumulation-inhibiting action and originated from a microorganism.
Provided is the method for producing new FKI-1746-1 and FKI-1746-2 substances, characterized by culturing a microorganism belonging to genus Aspergillus and having ability to produce the FKI-1746-1 and FKI-1746-2 substances, especially Aspergillus clavatonanicus FKI-1746 (FERM AP-21482), in a culture medium, and then collecting the FKI-1746-1 and/or FKI-1746-2 substances from the culture product. The new substances have a macrophage intrafat drop accumulation-inhibiting action, and are effective for preventing and treating arteriosclerosis and diseases caused by the arteriosclerosis.
Inventors:
KODA HIROSHI
KOYAMA NOBUHIRO
MASUMA ROKURO
OMURA SATOSHI
KOYAMA NOBUHIRO
MASUMA ROKURO
OMURA SATOSHI
Application Number:
JP2008025155A
Publication Date:
August 20, 2009
Filing Date:
February 05, 2008
Export Citation:
Assignee:
KITASATO INST
International Classes:
C07D487/22; A61K31/519; A61K31/529; A61P9/10; A61P43/00; C07D519/00; C12N1/14; C12P17/12
Foreign References:
| WO2009096445A1 | 2009-08-06 | |||
| WO2009096445A1 | 2009-08-06 |
Other References:
JPN6012059423; Ｏｒｇａｎｉｃ Ｌｅｔｔｅｒｓ Ｖｏｌ．１０， Ｎｏ．２２, 2008, ｐ．５２７３-５２７６
JPN6012059426; Ｊｏｕｒｎａｌ ｏｆ Ａｎｔｉｂｉｏｔｉｃｓ Ｖｏｌ．４６， Ｎｏ．４, 1993, ｐ．５４５-５５３
JPN6012059423; Ｏｒｇａｎｉｃ Ｌｅｔｔｅｒｓ Ｖｏｌ．１０， Ｎｏ．２２, 2008, ｐ．５２７３-５２７６
JPN6012059426; Ｊｏｕｒｎａｌ ｏｆ Ａｎｔｉｂｉｏｔｉｃｓ Ｖｏｌ．４６， Ｎｏ．４, 1993, ｐ．５４５-５５３
JPN6012059426; Ｊｏｕｒｎａｌ ｏｆ Ａｎｔｉｂｉｏｔｉｃｓ Ｖｏｌ．４６， Ｎｏ．４, 1993, ｐ．５４５-５５３
JPN6012059423; Ｏｒｇａｎｉｃ Ｌｅｔｔｅｒｓ Ｖｏｌ．１０， Ｎｏ．２２, 2008, ｐ．５２７３-５２７６
JPN6012059426; Ｊｏｕｒｎａｌ ｏｆ Ａｎｔｉｂｉｏｔｉｃｓ Ｖｏｌ．４６， Ｎｏ．４, 1993, ｐ．５４５-５５３
Attorney, Agent or Firm:
Shoichi Hirose
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