Title:
NEW PROCESS FOR MANUFACTURE OF DEOXYSTREPTAMINE DERIVATIVES AND SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS
Document Type and Number:
Japanese Patent JPS5214746
Kind Code:
A
Abstract:
1502537 2 - Desoxy - streptamine derivatives ROUSSEL-UCLAF 23 July 1976 [23 July 1975] 30746/76 Heading C2C Novel N 1 - [L(-) - 2 - hydroxy - 4 - aminobutyryl] - 4 - O - [21 ,61 - diamino - 21 ,61 - didesoxy - α,D - glucopyranosyl] - 6 - O - [311 - methylamino - 311 ,411 ,611 - tridesoxy - α,D- xylohexopyranosyl] - 2 - desoxystreptamine (I) and addition salts thereof with mineral or organic acids are prepared by reacting 4-O- [21 ,61 - diamino - 21,61 - didesoxy - α,D - glucopyranosyl] - 6 - O - [311 - methylamino - 311 ,411 , 611 - tridesoxy - α,D - xylohexopyranosyl] - 2- desoxystreptamine with N - benzyloxycarbonyloxy-succinimide, reacting the resulting novel 4 - O - [21 - amino - 61 - benzyloxycarbonylamino - 21 ,61 - didesoxy - α,D - glucopyranosyl] - 6 - O - [311 - methylamino - 311 ,411 , 611 - tridesoxy - α,D - xylohexopyranosyl] - 2- desoxystreptamine with the N-hydroxysuccinimide ester of L-(-)-γ-benzyloxycarbonylamino - α - hydroxy - butyric acid and catalytically hydrogenating the resulting novel N 1 - [L - (-) - 2 - hydroxy - 4 - benzyloxycarbonylamino - butyryl] - 4 - O - [21 - amino- 61 - benzyloxycarbonylamino - 21 ,61 - didesoxy- α,D - glucopyranosyl] - 6 - O - [311 - methylamino - 311 ,411 ,611 - tridesoxy - α,D - xylohexopyranosyl] - 2 - desoxystreptamine, followed optionally by salification with an appropriate acid. Pharmaceutical compositions having antibiotic activity comprise, as active ingredient, the compound (I) or a pharmaceutically acceptable mineral or organic acid addition salt thereof, in association with a suitable pharmaceutical vehicle.
Inventors:
JIYAN BERUNAARU SHIYAZAN
JIYAN KUROODO GASUKU
JIYAN KUROODO GASUKU
Application Number:
JP8739976A
Publication Date:
February 03, 1977
Filing Date:
July 23, 1976
Export Citation:
Assignee:
ROUSSEL UCLAF
International Classes:
A61K31/70; A61K31/7028; A61K31/7034; A61K31/7036; A61P31/04; C07H15/222; B01J23/00; B01J25/00; C07B61/00; C07H15/234; (IPC1-7): A61K31/71; B01J23/40; B01J25/02; C07H1/00; C07H15/22