NEW PROTEIN AND METHOD FOR PRODUCING MEDICINE BY USING THE SAME

Japanese Patent JP2009167220

A

To provide proteins that can neutralize the actions of TNF.

The protein has a molecular weight of about 42,000 daltons in a first glycosylated form and has at the N-terminus an amino acid sequence: Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu (Xaa is H, a phenylalanine residue (Phe) or amino acid sequences; Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Vla Ala Phe, Pro Ala Gln Val Ala Phe, or Leu Pro Gln Val Ala Phe) and a mutein obtained by a proper substitution, deletion or addition of an amino acid or peptide for, from or to the protein or the change of a glycoside group without strongly lowering the action of the protein.

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LEMAIRE HANS-GEORG
HILLEN HEINZ
MOELLER ACHIM
DAUM LOTHAR
DOERPER THOMAS
SUBKOWSKI THOMAS

JP2009112440A

July 30, 2009

May 07, 2009

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ABBOTT GMBH & CO KG

A61K35/22; A61K38/00; C07K14/47; A61K38/17; A61K38/19; A61P7/00; A61P7/02; A61P7/04; A61P11/00; A61P19/00; A61P19/02; A61P19/08; A61P25/00; A61P29/00; A61P31/04; A61P37/00; A61P37/02; A61P37/08; A61P43/00; C07K1/18; C07K1/22; C07K7/08; C07K14/00; C07K14/435; C07K14/525; C07K14/715; C07K16/18; C12P21/02

Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki

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