Title:
特定のシクロリグナン類の新しい使用
Document Type and Number:
Japanese Patent JP5071910
Kind Code:
B2
Abstract:
The invention refers to the use of specific cyclolignans, wherein the carbon atoms in positions 9 and 9' have cis configuration, for inhibition of the insulin-like growth factor-1 receptor. Said compounds can be used for treatment of IGF-1 R dependent diseases, such as cancer, psoriasis, artherosclerosis and acromegaly. A preferred compound is picropodophyllin.
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Inventors:
Larsson I
Axelson Magnus
Axelson Magnus
Application Number:
JP2003506277A
Publication Date:
November 14, 2012
Filing Date:
June 19, 2002
Export Citation:
Assignee:
Accelerator AB
International Classes:
A61K31/365; A61K31/34; A61K31/36; A61P5/06; A61P9/10; A61P17/06; A61P35/00; A61P35/02; A61P43/00; C07D317/54; C07D317/70; C07D493/04
Domestic Patent References:
| JP9194368A | ||||
| JP62501360A | ||||
| JP61267541A |
Foreign References:
| WO2000000238A1 |
Other References:
Journal of Natural Products,1993,56(10),pp.1728-1736
Archiv der Pharmazie,1994,Vol.327,No.3,pp.175-179
Journal of Natural Products,1995,Vol.58,No.6,p.870-877
Journal of Pharmaceutical Sciences,1986,Vol.75,No.11,pp.1076-1080
Planta Medica,1993,Vol.59,No.3,p.246-249
Bioorganic & Medicinal Chemistry Letters,1995,Vol.5,No.21,pp.2465-2468
Indian Journal of Heterocyclic Chemistry,1996年,Vol.5,No.3,pp.185-188
Il Farmaco,2001,56(4),pp.297-304
Archiv der Pharmazie,1994,Vol.327,No.3,pp.175-179
Journal of Natural Products,1995,Vol.58,No.6,p.870-877
Journal of Pharmaceutical Sciences,1986,Vol.75,No.11,pp.1076-1080
Planta Medica,1993,Vol.59,No.3,p.246-249
Bioorganic & Medicinal Chemistry Letters,1995,Vol.5,No.21,pp.2465-2468
Indian Journal of Heterocyclic Chemistry,1996年,Vol.5,No.3,pp.185-188
Il Farmaco,2001,56(4),pp.297-304
Attorney, Agent or Firm:
Eiji Saegusa
Mutsuko Nakano
Mutsuko Nakano