PURPOSE: To obtain a novel compound which is useful as an anti-microbial because it shows powerful antimicrobial activity against gram-positive bacteria and can maintain the activity in blood for hours.
CONSTITUTION: A compound of the formula I [R1, R2 are H, COR (R is 1-3C straight-chain alkyl); R3 is 1-4C straight-chain alkyl, alkenyl) or its salts, for example, 4"-0-isoamyl-3"-0-methyl-9-O-propionylleucomycin V. The compound of the formula I (the case where both of R1 and R2 are H is excluded) is obtained by reaction of a compound of the formula II or its salt is allowed to react with pyridine and acetyl chloride. The compound of the formula II is novel, and obtained by using a compound in the leucomycin Fr group of the formula III as a starting substance.
KURIHARA KENICHI
KIKUCHI NOBUE
HARA OSAMU
SHIBAHARA MASAYUKI
