Title:
メプリンアルファ及びベータの新規な阻害剤
Document Type and Number:
Japanese Patent JP7179114
Kind Code:
B2
Abstract:
The present invention relates to novel hydroxamic acid derivatives as inhibitors of meprin β and/or α, pharmaceutical compositions comprising such compounds, methods for treatment or prophylaxis of diseases or conditions, especially such that are related to meprin β and/or α, and compounds and pharmaceutical compositions for use in such methods.
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Inventors:
Michael Werman
Mirko Buchholz
Hans-Ulrich Demut
Daniel Ramsbeck
Dagmar Schrenzig
Stephan Schilling
Mirko Buchholz
Hans-Ulrich Demut
Daniel Ramsbeck
Dagmar Schrenzig
Stephan Schilling
Application Number:
JP2021055206A
Publication Date:
November 28, 2022
Filing Date:
March 29, 2021
Export Citation:
Assignee:
Bibolyon Therapeutics NV
International Classes:
A61K31/165; C07C259/06; A61K31/401; A61P1/04; A61P9/10; A61P9/12; A61P11/00; A61P13/02; A61P13/10; A61P13/12; A61P17/02; A61P25/28; A61P29/00; A61P35/00; A61P43/00; C07D207/16
Domestic Patent References:
| JP2005536510A | ||||
| JP2003500389A | ||||
| JP2019519477A |
Foreign References:
| US20070066646 | ||||
| WO2009036012A1 | ||||
| WO2008033745A1 | ||||
| WO2005020973A2 | ||||
| WO2009036057A1 | ||||
| WO2005073180A1 | ||||
| WO2015024011A2 | ||||
| CN105237478A | ||||
| WO2007003594A1 |
Other References:
Breger, M. A.,Biological activity of cycloserine and some of its analogs and homologs,Antibiotiki (Moscow) ,1961年,6(No. 9),26-9
Riva, Elena; Gagliardi, Stefania; Mazzoni, Caterina; Passarella, Daniele; Rencurosi, Anna; Vigo, Daniele; Martinelli, Marisa,Efficient Continuous Flow Synthesis of Hydroxamic Acids and Suberoylanilide Hydroxamic Acid Preparation,Journal of Organic Chemistry ,2009年,74(9),,3540-3543
ATLI THORARENSEN; ET AL,IDENTIFICATION OF NOVEL POTENT HYDROXAMIC ACID INHIBITORS OF PEPTIDYL DEFORMYLASE AND 以下備考,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,英国,PERGAMON,2001年,VOLUME 11, ISSUE 11,PAGES 1355-1358,http://dx.doi.org/10.1016/S0960-894X(01)00242-6,THE IMPORTANCE OF THE HYDROXAMIC ACID FUNCTIONALITY ON INHIBITION
Ozawa, Tomohiro; Iwai, Kouji; Jitsukawa, Koichiro; Masuda, Hideki; Einaga, Hisahiko,Thermodynamic and kinetic studies of formation mechanisms of iron(III) complexes with Nα-salicyl-L-alaninehydroxamic acid, L-alaninehydroxamic acid and Nα-salicyl-L-alanine: role of hydroxamate group on enhancement of the stability,Polyhedron ,1994年,13(10),,1523-38
Biggs, D. F.; Coutts, R. T.; Selley, M. L.; Towill, G. A.,Potential hypotensive compounds. Substituted 3-aminopropionates and 3-aminopropionohydroxamic acids,Journal of Pharmaceutical Sciences,1972年,61(11),1739-45
DATABASE REGISTRY [online] CHEMICAL ABSTRACT SERVICE, US; Retrieved from STN,2011年12月04日,RN 1348350-46-8,N-ヒドロキシ-2-[[[4-[[4-(フェニルメトキシ)フェニル]スルホニル]-3-ピリジニル]メチル]アミノ]-アセトアミド
DATABASE REGISTRY [online] CHEMICAL ABSTRACT SERVICE, US; Retrieved from STN,2011年12月04日,RN 1348300-32-2,3-[[[(1R)-1-[(ヒドロキシアミノ)カルボニル]-2-メチルプロピル]アミノ]メチル]-4-ピリジンスルホン酸メチルエステル
DATABASE REGISTRY [online] CHEMICAL ABSTRACT SERVICE, US; Retrieved from STN,2011年12月04日,RN 1348453-18-8,N-ヒドロキシ-2-[[[4-[(4-メトキシフェニル)スルホニル]-3-ピリジニル]メチル]アミノ]-3-メチル-ブタンアミド
DATABASE REGISTRY [online] CHEMICAL ABSTRACT SERVICE, US; Retrieved from STN,2008年06月09日,RN 1026679-55-9,2-[[[4-[[4-(4-フルオロフェノキシ)フェニル]スルホニル]-3-ピリジニル]メチル]アミノ]-N-ヒドロキシ-2-メチル-プロパンアミド
DATABASE REGISTRY [online] CHEMICAL ABSTRACT SERVICE, US; Retrieved from STN,2008年06月08日,RN 1026494-19-8,2-[[[4-[[4-(4-フルオロフェノキシ)フェニル]スルホニル]-3-ピリジニル]メチル]アミノ]-N-ヒドロキシ-アセトアミド
Riva, Elena; Gagliardi, Stefania; Mazzoni, Caterina; Passarella, Daniele; Rencurosi, Anna; Vigo, Daniele; Martinelli, Marisa,Efficient Continuous Flow Synthesis of Hydroxamic Acids and Suberoylanilide Hydroxamic Acid Preparation,Journal of Organic Chemistry ,2009年,74(9),,3540-3543
ATLI THORARENSEN; ET AL,IDENTIFICATION OF NOVEL POTENT HYDROXAMIC ACID INHIBITORS OF PEPTIDYL DEFORMYLASE AND 以下備考,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,英国,PERGAMON,2001年,VOLUME 11, ISSUE 11,PAGES 1355-1358,http://dx.doi.org/10.1016/S0960-894X(01)00242-6,THE IMPORTANCE OF THE HYDROXAMIC ACID FUNCTIONALITY ON INHIBITION
Ozawa, Tomohiro; Iwai, Kouji; Jitsukawa, Koichiro; Masuda, Hideki; Einaga, Hisahiko,Thermodynamic and kinetic studies of formation mechanisms of iron(III) complexes with Nα-salicyl-L-alaninehydroxamic acid, L-alaninehydroxamic acid and Nα-salicyl-L-alanine: role of hydroxamate group on enhancement of the stability,Polyhedron ,1994年,13(10),,1523-38
Biggs, D. F.; Coutts, R. T.; Selley, M. L.; Towill, G. A.,Potential hypotensive compounds. Substituted 3-aminopropionates and 3-aminopropionohydroxamic acids,Journal of Pharmaceutical Sciences,1972年,61(11),1739-45
DATABASE REGISTRY [online] CHEMICAL ABSTRACT SERVICE, US; Retrieved from STN,2011年12月04日,RN 1348350-46-8,N-ヒドロキシ-2-[[[4-[[4-(フェニルメトキシ)フェニル]スルホニル]-3-ピリジニル]メチル]アミノ]-アセトアミド
DATABASE REGISTRY [online] CHEMICAL ABSTRACT SERVICE, US; Retrieved from STN,2011年12月04日,RN 1348300-32-2,3-[[[(1R)-1-[(ヒドロキシアミノ)カルボニル]-2-メチルプロピル]アミノ]メチル]-4-ピリジンスルホン酸メチルエステル
DATABASE REGISTRY [online] CHEMICAL ABSTRACT SERVICE, US; Retrieved from STN,2011年12月04日,RN 1348453-18-8,N-ヒドロキシ-2-[[[4-[(4-メトキシフェニル)スルホニル]-3-ピリジニル]メチル]アミノ]-3-メチル-ブタンアミド
DATABASE REGISTRY [online] CHEMICAL ABSTRACT SERVICE, US; Retrieved from STN,2008年06月09日,RN 1026679-55-9,2-[[[4-[[4-(4-フルオロフェノキシ)フェニル]スルホニル]-3-ピリジニル]メチル]アミノ]-N-ヒドロキシ-2-メチル-プロパンアミド
DATABASE REGISTRY [online] CHEMICAL ABSTRACT SERVICE, US; Retrieved from STN,2008年06月08日,RN 1026494-19-8,2-[[[4-[[4-(4-フルオロフェノキシ)フェニル]スルホニル]-3-ピリジニル]メチル]アミノ]-N-ヒドロキシ-アセトアミド
Attorney, Agent or Firm:
Murayama Yasuhiko
Shinya Mihiro
Tatsuhiko Abe
Shinya Mihiro
Tatsuhiko Abe
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