CYCLOHEXANEDIAMIDE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES

Title:

CYCLOHEXANEDIAMIDE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES

Document Type and Number:

WIPO Patent Application WO/2013/161980

Kind Code:

A1

Abstract:

The purpose of the present invention is to provide: a compound having an sEH-inhibiting activity; and a medicinal agent which has an sEH-inhibiting activity and therefore can exhibit a therapeutic effect and a prophylactic effect on chronic kidney diseases and pulmonary hypertension. The present invention provides a cyclohexanediamide derivative represented by chemical formula (1).

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Inventors:

KUROSAWA SATOSHI (JP)
NISHIMURA YUTAKA (JP)
KATO YUKO (JP)
FUCHI NOBUHIRO (JP)
AOKI TAKUMI (JP)
YAMADA MASATERU (JP)
YAMADA NAOHIRO (JP)

Application Number:

PCT/JP2013/062335

Publication Date:

October 31, 2013

Filing Date:

April 26, 2013

Export Citation:

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Assignee:

TORAY INDUSTRIES (JP)

International Classes:

C07C255/64; A61K31/165; A61K31/275; A61P9/12; A61P13/12; A61P43/00; C07C237/24; C07C311/06

Foreign References:

JP2003533519A	2003-11-11
JP2006528660A	2006-12-21
JP2008526858A	2008-07-24
JP2006525327A	2006-11-09

Other References:

JYOTI R. PATEL ET AL.: "Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 3, 2007, pages 750 - 755

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