Title:
NOVEL OPTICALLY ACTIVE PROPIONIC ACID ESTER DERIVATIVE AND PREPARATION THEREOF
Document Type and Number:
Japanese Patent JPS61145159
Kind Code:
A
Abstract:
NEW MATERIAL:(+)-(2R*,3R*)-3-(2-aminophenylthio)-2-hydrox-y-3-(4-met-hoxy- phenyl)propionic acid ester of formula I (R is 1W4C lower alkyl).
USE: An intermediate of diltiazem hydrochloride useful as a coronary vasodilator.
PREPARATION: The compound of formula I can be prepared by reacting (-)-(2 R*,3R*)-2,3-epoxy-3-(4-methoxyphenyl)propi-onic acid ester of formula II with 2-aminothiophenol in a solvent (e.g. toluene) at 100W140°C.
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Inventors:
HAYASHI MASATOSHI
YAMAMOTO MASAO
YAMAMOTO MASAO
Application Number:
JP26743584A
Publication Date:
July 02, 1986
Filing Date:
December 20, 1984
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO
International Classes:
C07B53/00; C07B31/00; C07B57/00; C07C67/00; C07C313/00; C07C323/56; C07D281/10; (IPC1-7): C07B57/00; C07C149/273; C07D281/10
Domestic Patent References:
| JPS57136581A | 1982-08-23 |