NOVEL PHENYLCARBAMATE DERIVATIVE AND ANALGESIC CONTAINING THE SAME

Japanese Patent JPS577459

A

NEW MATERIAL:Phenylcarbamate derivatives of formula I [R1 is H, alkyl, OR1' (R1' is alkyl or amino-substituted alkyl); R2, R3 are H, alkyl, alkenyl, cycloalkyl; R4 is H, alkyl, alkylcarbonyl; R5 is carbamoylalkyl, alkylsulfonyl; R6 is H, alkyl].

EXAMPLE: (2-Ethoxy-4-acetoxyacetamidephenyl)-morpholinocarboxylate.

USE: Analgesic: they form almost no methaemoglobin, show low toxicity and are used for warm-blood animals including men.

PREPARATION: The reaction of a derivative of formula II with a substituted or unsubstituted alkyl, alkenyl or allyl isocyanate gives the compound of formula I. The reaction is usually conducted in an inert solvent such as methylene chloride or chloroform.

WO/2005/073205	SELECTIVE ESTROGEN RECEPTOR MODULATORS
JP3474940	MEDICINAL RESISTANCE OVERCOMING AGENT
WO/2009/147057	POLYMERIZABLE TYPE II PHOTOINITIATORS AND CURABLE COMPOSITIONS

FUJIMURA HAJIME
OKAMOTO KIHACHIROU
TETSUO MATAICHI
KITAURA MASAKI
NISHIZAWA SUSUMU
TAMAKI SATOSHI
MATSUI HIROSHI
KAWAMURA TOSHIYUKI

JP8078380A

January 14, 1982

June 13, 1980

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KYOTO PHARMA IND

C07D295/18; A61K31/27; A61K31/395; A61K31/397; A61K31/40; A61K31/415; A61K31/445; A61K31/455; A61K31/495; A61K31/496; A61K31/535; A61P25/04; C07C67/00; C07C239/00; C07C271/08; C07C271/44; C07C271/46; C07C301/00; C07C311/04; C07D205/04; C07D213/80; C07D213/82; C07D233/32; C07D241/08; C07D263/58; C07D295/08; C07D295/20; (IPC1-7): A61K31/27; A61K31/395; A61K31/40; A61K31/415; A61K31/445; A61K31/455; A61K31/495; A61K31/535; C07C125/067; C07C125/075; C07C127/19; C07C143/79; C07D205/04; C07D213/80; C07D213/82; C07D233/32; C07D241/08; C07D263/58; C07D295/08; C07D295/20

JPS5416449A	1979-02-07
JPS51133250A	1976-11-18
JPS51112520A	1976-10-05

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