NOVEL PIPERIDINE COMPOUNDS AND THEIR CARBINOL ANALOGUES AND MANUFACTURE

Title:

NOVEL PIPERIDINE COMPOUNDS AND THEIR CARBINOL ANALOGUES AND MANUFACTURE

Document Type and Number:

Japanese Patent JPS57114570

Kind Code:

A

Abstract:

1-[(3- or 4-Benzoylphenyl)-lower-alkyl]-[(CH2)n-N=B]-substituted-piperidines, useful as anti-asthmatic, anti-allergic, anti-cholinergic, bronchodilator and anti-inflammatory agents, are prepared by alkylation of an appropriate substituted piperidine with a (3- or 4-benzoylphenyl)-lower-alkyl halide or tosylate; by reaction of a 1-[2-(3- or 4-lithiophenyl)-lower-alkyl]- DIFFERENTIAL (CH2)n-N=]-substituted-piperidine with benzonitrile and hydrolysis of the resulting benzimidoyl compound; or by reduction of a 1-[ alpha -(3- or 4-benzoylphenyl)-lower-alkanoyl]-[(CH2)n-N=B]-substituted-piperidine.

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Inventors:

BAANAADO REON ZENITSUTSU

Application Number:

JP18610881A

Publication Date:

July 16, 1982

Filing Date:

November 19, 1981

Export Citation:

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Assignee:

STERLING DRUG INC

International Classes:

C07D309/12; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/445; A61K31/4468; A61P11/08; A61P25/04; A61P29/00; A61P37/08; A61P43/00; C07C29/14; C07C45/00; C07C49/83; C07C67/00; C07C301/00; C07C303/32; C07C309/73; C07D211/26; C07D211/58; C07D213/38; C07D213/75; C07D309/04; (IPC1-7): A61K31/445; C07C29/14; C07C33/46; C07C49/83; C07C147/06; C07D211/26; C07D211/58; C07D213/38; C07D213/75; C07D309/12

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