Title:
NOVEL PROPANOLAMINE ETHER COMPOUND AND PREPARATION THEREOF
Document Type and Number:
Japanese Patent JPS5242831
Kind Code:
A
Abstract:
New propanolamine derivs. have formula (I): In the formula, Ar = aryl (opt. substd. by halo, CF3, alkyl or alkoxy) or another aromatic gp. such as pyridyl; R1 = alkyl, cycloalkyl or aryl (opt. substd. by halo, CF3, alkyl or alkoxy); R = opt. branched alkyl, aralkyl or aryl and A = tert. amino such as pyrrolidino, piperidino, morpholino or dialkylamino. Used for treatment of angina pectoris by admin. in daily doses of 100-800 mg by usual routes. (I) have oral LD50 in mice of about 500 mg/kg. Typically, the specific cpd. 1-(3-isobutoxy-2-(4-chlorophenyl-benzoylamino)propyl)-pyrrolidine is pred. by reaction of parachlorobenzanilide with sodiumamide and 1-(3-isobutyoxy-2-chloropropyl)-pyrrolidine in xylene.
Inventors:
ROORAN IBU MOBERUNEI
NORUBEERU BIYUSHIYU
JIYATSUKU MOREIRU
JIYATSUKU SHIMON
ANDORE MONTEEYU
NORUBEERU BIYUSHIYU
JIYATSUKU MOREIRU
JIYATSUKU SHIMON
ANDORE MONTEEYU
Application Number:
JP11709276A
Publication Date:
April 04, 1977
Filing Date:
September 29, 1976
Export Citation:
Assignee:
CT EUROP RUSHIERUSHIYU MOOBERU
International Classes:
C07D295/12; A61K31/165; A61K31/40; A61K31/44; A61K31/4402; A61K31/445; A61K31/535; A61K31/5375; A61P9/08; A61P9/10; C07C67/00; C07C231/00; C07C231/12; C07C233/18; C07C233/25; C07C233/36; C07C233/56; C07C233/62; C07C233/78; C07D213/75; C07D295/13; (IPC1-7): A61K31/165; A61K31/40; A61K31/44; A61K31/445; A61K31/535; C07C103/30; C07D207/06; C07D295/12