NEW MATERIAL:The compound of formula I {R1 is protectable amino; R is C(W)(Y)-Z [Z is CO2R3 (R3 is H, alkali metal, etc.), CO2-, etc.; W is R4 (R4 is H, 1W6C lower alkyl, etc.), F, OR4, etc.; Y is F, OR4, etc.]; A is group of formula II (B is H or nucleophilic compound residue), etc.} or the compound of formula III {R5 is group of formula CH2C(T)U)-Z [T is R4, F, OR4, etc.]}.
EXAMPLE: 2-( 2-Triphenylmethylamino-1, 3-thiazol-4-yl )-2-[1-t-butyloxy-carbon ylethenyl)oxyimino]acetic acid.
USE: Antibacterial agent and its intermediate.
PREPARATION: The compound of formula Ie can be produced by acylating the compound of formula XI(R10 is same as R2 and R5) or its reactive derivative at the carboxyl group or its salt and the compound of formula XXIV or its reactive derivative at the amino group.
| JPS60132918 | ORAL CEPHALOSPORIN COMPOSITION |
| JPS58135892 | CEPHALOSPORIN DERIVATIVE |
OGASAWARA YOSHIAKI
NAKAZAWA MASAKAZU
YASUDA NAOHIKO
ONUKI TAKASHI
KATO NOBUAKI
Next Patent: TRICYCLIC DERIVATIVE