Title:
TRICYCLIC DERIVATIVE
Document Type and Number:
Japanese Patent JPS61254585
Kind Code:
A
Abstract:
The invention provides a compound of formula (1):-
and pharmaceutically acceptable salts thereof, where X<1> is oxygen; sulphur; -NR<2>- (where R<2> is hydrogen, C1-6alkyl or C1-6alkanoyl); -CHR<3>-; -CH2CHR<3>-; -O-CHR<3>-; or -S-CHR<3> - (where R<3> is hydrogen or C1-6alkyl);
X<3> and X<4> are the same or different and represent a fused benzo or pyrido ring, each ring being optionally substituted with C1-6alkyl, C1-6alkoxy or halogen;
b is from 2 to 5;
r is 1 or 2; and
R<1> is hydrogen, C1-6alkyl or a group -CH2R<5> and R<5> is pyridyl optionally bearing one or two substituents which are the same or different and are C1-6alkyl, C1-6alkoxy, halogen or hydroxy; or is phenyl or pyridyl bearing a carboxy, carboxamido, sulphonamido or hydroxy-C1-6alkyl group and optionally bearing a C1-6alkyl C1-6alkoxy, hydroxy or halogen substituent; or is N-oxo-pyridyl optionally bearing a C1-6alkyl, C1-6alkoxy, or halogen substituent.
The compounds are useful as histamine H1-antagonists.
Inventors:
ANDORIYUU DERITSUKU GURIBURU
ROBAATO JIYON AIFU
ROBAATO JIYON AIFU
Application Number:
JP9781286A
Publication Date:
November 12, 1986
Filing Date:
April 25, 1986
Export Citation:
Assignee:
SMITHKLINE LTD
International Classes:
A61K31/00; A61P11/08; A61P27/16; A61P37/08; A61P43/00; C07D281/14; C07D417/12; C07D417/14; C07D471/04; C07D471/14; C07D487/04; C07D487/14; C07D513/04; (IPC1-7): A61K31/645; C07D213/00; C07D221/00; C07D223/00; C07D279/00; C07D285/00; C07D417/12; C07D417/14; C07D513/04
Attorney, Agent or Firm:
Aoyama Aoi