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Title:
NOVEL TROPOLONE DERIVATIVE
Document Type and Number:
Japanese Patent JPS62126190
Kind Code:
A
Abstract:

NEW MATERIAL:A compound expressed by formula I (R represents heterocyclic group).

EXAMPLE: Bis(2-hydroxy-6-isopropyltropon-3-yl)-(thiophen-2-yl)methane.

USE: An anticacer agent.

PREPARATION: For example, a compound expressed by the formula RCH (OC2H5)2 (example; thiophenecarbaldehyde-dithioacetal, etc.) is reacted with hinokitiol expressed by formula II in a solvent (example; xylene, etc.) or without using any solvent in the presence or absence of a catalyst (preferably potassium t-butoxide) usually at 150W180°C for 1W10hr. As for the starting material, nor mally 0.5W1mol of the former and preferably 0.01W1mol catalyst are used based on 1mol of the latter.


Inventors:
YAMATO MASATOSHI
Application Number:
JP26655585A
Publication Date:
June 08, 1987
Filing Date:
November 26, 1985
Export Citation:
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Assignee:
YAMATO MASATOSHI
International Classes:
C07D333/22; A61K31/33; A61K31/34; A61K31/341; A61K31/38; A61K31/381; A61P35/00; C07D213/50; C07D307/46; C07D521/00; (IPC1-7): A61K31/33; A61K31/34; A61K31/38; C07D213/50; C07D307/46; C07D333/22; C07D521/00
Attorney, Agent or Firm:
Minoru Nakamura