Title:
ORGANIC ACID SALT OF 5,6,7,8-TETRAHYDRO-D-NEOPTERIN AND ITS PRODUCTION
Document Type and Number:
Japanese Patent JP3433301
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new compound producible in high yield in easily purifiable state having extremely high crystallinity and, accordingly, practically usable as an agent for the treatment of side actions of a cancer-suppressing agent and a carcinostatic agent or an agent for the treatment of diseases relating to active oxygen.
CONSTITUTION: An organic acid salt of the 6R or 6S isomer of 5,6,7,8- tetrahydro-D-neopterin expressed by formula I or formula II e.g. (R)- tetrahydroneopterin.(-)camphorsulfonic acid salt. The compound can be produced by treating 5,6,7,8-tetrahydro-Dneopterin dihydrochloride with an ion exchange resin (preferably a strongly basic ion exchange resin) containing adsorbed organic acid (preferably camphorsulfonic acid, tartaric acid or oxalic acid) to effect the ion exchange, dissolving the produced mixture of 6R isomer and 6S isomer in a mixed solvent consisting of water, alcohol or mineral acid and carrying out fractional crystallization of the compound from the solution.
Inventors:
Toshiaki Waga
Ya Murayama
Ya Murayama
Application Number:
JP31752493A
Publication Date:
August 04, 2003
Filing Date:
November 25, 1993
Export Citation:
Assignee:
Asahi Breweries, Ltd.
Torii Pharmaceutical Co., Ltd.
Torii Pharmaceutical Co., Ltd.
International Classes:
C07D475/04; A61K31/505; A61K31/519; A61P35/00; A61P43/00; C07B57/00; (IPC1-7): C07D475/04; C07B57/00
Domestic Patent References:
| JP574990A |
Attorney, Agent or Firm:
Eiko Funahashi