心血管疾患の予測および治療のためのオステオポンチン

Title:

心血管疾患の予測および治療のためのオステオポンチン

Document Type and Number:

Japanese Patent JP2010520181

Kind Code:

A

Abstract:

Osteopontin for the prediction and treatment of cardiovascular diseases The present invention relates to the use of endothelial progenitor cells (EPCs) and osteopontin for the treatment of cardiovascular diseases or complications. The invention also relates to the use of EPC osteopontin levels as a marker of the risk of the development of these cardiovascular complications. In particular, the invention provides compositions and methods based on osteopontin and the genes encoding osteopontin.

Inventors:

O'Brien, Timothy
Barry, frank
Liu E. Lone, Aaron
Summary, Afshin
Duffy, Angela

Application Number:

JP2009551228A

Publication Date:

June 10, 2010

Filing Date:

March 03, 2008

Export Citation:

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Assignee:

National University of Ireland Galway

International Classes:

A61K35/12; A61K35/28; A61K35/44; A61K38/00; A61K39/395; A61K48/00; A61L15/44; A61L17/00; A61L31/00; A61P3/10; A61P9/00; A61P9/10; G01N33/15; G01N33/50

Domestic Patent References:

JP2006217801A	2006-08-24
JP2004509847A	2004-04-02
JP2001503427A	2001-03-13

Foreign References:

WO2007012764A2	2007-02-01
WO2006060779A2	2006-06-08
WO2006042017A2	2006-04-20
WO2005085424A2	2005-09-15

Other References:

JPN6013005455; ＡＳＯＵ，Ｙ．　ｅｔ　ａｌ: 'Ｏｓｔｅｏｐｏｎｔｉｎ　ｆａｃｉｌｉｔａｔｅｓ　ａｎｇｉｏｇｅｎｅｓｉｓ，　ａｃｃｕｍｕｌａｔｉｏｎ　ｏｆ　ｏｓｔｅｏｃｌａｓｔｓ，　ａｎｄ　ｒｅｓｏｒｐｔｉｏｎ　ｉｎ　ｅｃｔｏｐｉｃ　ｂｏｎｅ' ＥｎｄｏｃｒｉｎｏｌｏｇｙＶｏｌ．１４２，　Ｎｏ．３, 2001, ｐ．１３２５-３２
JPN5010006936; ＩＩ　ＭＡＳＡＡＫＩ: ＣＩＲＣＵＬＡＴＩＯＮＶ１１２　Ｎ１７　ＳＵＰＰＬ　Ｓ, 200510, Ｐ．Ｕ２１９
JPN5010006937; ＴＡＫＡＧＩ　Ｈ: ＪＡＰＡＮＥＳＥ　ＪＯＵＲＮＡＬ　ＯＦ　ＯＰＨＴＨＡＬＭＯＬＯＧＹＶ４６　Ｎ３, 2002, Ｐ２７０-２７８
JPN6013005459; ＨＡＭＡＤＡ，Ｙ．　ｅｔ　ａｌ: 'Ａｎｇｉｏｇｅｎｉｃ　ａｃｔｉｖｉｔｙ　ｏｆ　ｏｓｔｅｏｐｏｎｔｉｎ-ｄｅｒｉｖｅｄ　ｐｅｐｔｉｄｅ　ＳＶＶＹＧＬＲ' Ｂｉｏｃｈｅｍ　Ｂｉｏｐｈｙｓ　Ｒｅｓ　ＣｏｍｍｕｎＶｏｌ．３１０，　Ｎｏ．１, 2003, ｐ．１５３-７

Attorney, Agent or Firm:

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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