Title:
【発明の名称】表面付着細菌の活発な増殖を予測する方法
Document Type and Number:
Japanese Patent JPH08505533
Kind Code:
A
Abstract:
The present invention described provides a start microbial replication factor, as well as methods for assaying and using the start microbial replication factor. A start microbial replication factor can be used to stimulate the growth of bacteria in suspension or bound to a surface. Agents that inhibit or enhance a start microbial replication factor can also be identified. The present invention also describes processes to treat or control the growth of bacteria which are bound to surfaces. Both proliferation and metabolism of bacteria which are adhered to surfaces are independent of both time and nutrient supply. Growth of adherent bacteria is density dependent. The present invention also provides a process to predict when bacterial growth will exhibit rapid growth on a surface. The invention also provides strains of transformed bacteria and methods of using the bacteria strains to measure microbial growth in the presence of absence of a start microbial replication factor. The transformed bacteria have a bacterial reporter gene under the control of a promoter whose expression is coordinately regulated with cell growth.
Inventors:
Bloomquist, Cynthia Gee
Douglas, William
Danny, Gully
Lil Jemmark, William
Rayleigh, Bernard
Douglas, William
Danny, Gully
Lil Jemmark, William
Rayleigh, Bernard
Application Number:
JP51634694A
Publication Date:
June 18, 1996
Filing Date:
January 14, 1994
Export Citation:
Assignee:
REGENTS OF THE UNIVERSITY OF MINNESOTA
International Classes:
A61K31/70; A61K38/00; A61P1/02; A61P31/12; C12N1/21; C12N1/38; C12N15/09; C12N15/62; C12Q1/00; C12Q1/02; G01N33/50; C12Q1/18; C12Q1/68; C12R1/46; (IPC1-7): C12Q1/00; A61K31/70; A61K38/00; C12N1/21; C12N15/09; C12Q1/18; C12Q1/68; G01N33/50
Attorney, Agent or Firm:
Kunihiko Ohashi (1 outside)