Title:
二重コア－シェル構造を有する難溶性カンプトテシン化合物を含む粒子、薬剤学的組成物及びその製造方法
Document Type and Number:
Japanese Patent JP7027666
Kind Code:
B2
Abstract:
A drug delivery system having an inner core-shell like structure containing a poorly soluble camptothecin compound and a water-soluble camptothecin compound, and an outer amphiphilic polymer shell surrounding the inner core-shell like structure, a manufacturing method therefor, and uses of the drug delivery system in treating cancer are disclosed. The core-shell structured particles form very stable particles and show a mono-distribution of particles before and after freeze-drying. The particles show excellent results compared with existing particles which do not contain the inner core-shell like structure, in animal efficacy tests and pharmacokinetic tests.
Inventors:
Park, Yong Hwan
Lee, Il Hyun
Lee, Il Hyun
Application Number:
JP2020520413A
Publication Date:
March 02, 2022
Filing Date:
June 22, 2018
Export Citation:
Assignee:
NS Bioscience Incorporated
International Classes:
A61K31/4745; A61K9/14; A61K9/51; A61K47/34; A61P35/00
Domestic Patent References:
| JP2013514278A |
Foreign References:
| US20100203150 |
Attorney, Agent or Firm:
Atsushi Nakajima
Kato Kazuho
Kato Kazuho