PHARMACEUTICAL AND METHOD FOR TREATING HYPOXIA AND SCREENING METHOD THEREFOR

Title:

PHARMACEUTICAL AND METHOD FOR TREATING HYPOXIA AND SCREENING METHOD THEREFOR

Document Type and Number:

Japanese Patent JP2009040785

Kind Code:

A

Abstract:

To provide a novel method and the like for treating hypoxia.

This method is for identifying prolylhydroxylase regulatory factor comprises following steps: (a) a step for bringing prolylhydroxylase, a hypothetic prolylhydroxylase regulatory factor and a light-generating fused protein into contact with one another, the photogenerated fused protein comprising an HIF polypeptide portion exhibiting a bonding property to prolylhydroxylase and a photogenerated peptide portion, where the photogeneration by the photogenerated peptide portion changes upon the bond of prolylhydroxylase to the HIF polypeptide portion under a condition favorable for bonding prolylhydroxylase to HIF thereby to form a specimen; and (b) a step for determining the capability of the hypothetic prolylhydroxylase regulatory factor regulating prolylhydroxylase by measuring light generated in the specimen.

Inventors:

KAELIN WILLIAM G
IVAN MIRCEA

Application Number:

JP2008204893A

Publication Date:

February 26, 2009

Filing Date:

August 07, 2008

Export Citation:

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Assignee:

DANA FARBER CANCER INST INC

International Classes:

A61K45/00; A61K31/7088; A61K38/00; A61K38/02; A61K38/44; A61K39/395; A61K47/42; A61K47/48; A61K48/00; A61P3/10; A61P7/02; A61P7/12; A61P9/00; A61P9/10; A61P11/00; A61P13/00; A61P13/12; A61P25/00; A61P35/00; A61P43/00; C07K14/47; C12N15/09; C12Q1/02; C12Q1/25; C12Q1/26; G01N21/76; G01N33/15; G01N33/50; G01N33/542; G01N33/573

Attorney, Agent or Firm:

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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