フェニル誘導体および血栓塞栓性疾患または腫瘍の処置におけるこれらの使用 - Merck Patent Gesellschaft mit beschraenkter Haftung

Title:

フェニル誘導体および血栓塞栓性疾患または腫瘍の処置におけるこれらの使用

Document Type and Number:

Japanese Patent JP2004525119

Kind Code:

A

Abstract:

Compounds of the formula (I) in which R<1 >is CN, or C(=NH)-NH2, CON(R<3>)2 or [C(R<4>)2]nN(R<3>)2, each of which is unsubstituted or monosubstituted by C(=O)R<3>, COOR<3>, or<3 >or by a conventional amino-protecting group, or W is -NR<3>CO-, -NR<3>COC(R<4>)2, NR<3>C(R<4>)2) or -C(R<4>)2NR<3>C(<4>)2-, X is -C(R<3>)2-, -[C(R<3>)2]2-, -C(R-<3>)2O- or -C(R<3>)2NR<3>, Y is alkylene, cycloalkylene, Het-diyl or Ar-diyl, T is OR<3>, N(R<3>)2, N(R<3>)2CON(R<3>)2, a monocyclic or bicyclic, saturated, unsaturated or aromatic heterocyclic radical having from 1 to 4 N, O and/sor S atoms which is unsubstituted or monosubstituted, disubstituted or trisubstituted, or a phenyl radical which is unsubstituted or monosubstituted, disubstituted or trisubstituted are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders and for the treatment of tumours.

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Inventors:

Medellsky, Werner
Uraszik, Horst
Dolsh Dieter
Zakura Kydis, Christos
Glitz, johannes
Burns, christopher
Cezanne, Bertram

Application Number:

JP2002569792A

Publication Date:

August 19, 2004

Filing Date:

February 04, 2002

Export Citation:

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Assignee:

Merck Patent Gesellschaft mit beschraenkter Haftung

International Classes:

A61K31/167; A61K31/17; A61K31/18; A61K31/275; A61K31/4015; A61K31/421; A61K31/4412; A61K31/45; A61K31/50; A61K31/5375; A61P7/02; A61P9/10; A61P25/00; A61P25/28; A61P29/00; A61P35/00; A61P35/04; A61P43/00; C07C237/42; C07C255/60; C07C257/18; C07C275/34; C07C311/08; C07C311/39; C07C311/44; C07C317/22; C07D207/27; C07D211/76; C07D213/64; C07D237/14; C07D263/22; C07D265/32; C07D271/06; C07D271/07; C07D413/12; C07D207/26; (IPC1-7): C07C257/18; A61K31/167; A61K31/17; A61K31/18; A61K31/275; A61K31/4015; A61K31/421; A61K31/4412; A61K31/45; A61K31/50; A61K31/5375; A61P7/02; A61P9/10; A61P25/00; A61P25/28; A61P29/00; A61P35/00; A61P35/04; A61P43/00; C07C311/08; C07C311/39; C07C317/22; C07D207/27; C07D211/76; C07D213/64; C07D237/14; C07D263/22; C07D265/32; C07D271/06

Attorney, Agent or Firm:

Kiyoji Kuzuwa

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