Title:
PHOSPHOLIPASE A2 INHIBITOR
Document Type and Number:
Japanese Patent JPH07223964
Kind Code:
A
Abstract:
PURPOSE: To provide the subject inhibitor containing a specific acteoside and a carrier, exhibiting phospholipase A inhibiting action, having extremely low toxicity and side action, effective for the treatment, etc., of inflammatory diseases such as arthrorheumatic collagenosis and useful as pharmaceuticals, health food raw materials, etc. CONSTITUTION: The objective inhibitor contains 3,4-dihydroxy-β-phenethyl-O-α-L- rhamnopyranosyl(1-3)-4-O-caffeoyl-β-glucopyranoside expressed by the formula, a compound obtained by protecting the hydroxyl group of the above compound with acetyl group or their salts in combination with a pharmacologically permissible carrier. The compound of the formula can be produced e.g. by inducing a callus cell from a section of the sprout of a gum tree, proliferating the cell and separating from the cell by solvent extraction, chromatography, etc. The daily administration rate of the objective inhibitor for adult is 0.01-1,000 mg/kg for intravenous or intramuscular administration and 0.5-2,000 mg/kg for oral administration in terms of the compound of the formula.
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Inventors:
RICHIYAADO HARISU
JIYANETSUTO KAA
UIRIAMU GARUBUREISU
KAWASHIMA ATSUSHI
NIWANO MITSURU
MIMURA MORIO
JIYANETSUTO KAA
UIRIAMU GARUBUREISU
KAWASHIMA ATSUSHI
NIWANO MITSURU
MIMURA MORIO
Application Number:
JP1047494A
Publication Date:
August 22, 1995
Filing Date:
February 01, 1994
Export Citation:
Assignee:
DU PONT MERCK PHARMA
KOBE STEEL LTD
KOBE STEEL LTD
International Classes:
C07H15/18; A61K31/70; A61K31/7028; A61P29/00; A61P43/00; (IPC1-7): A61K31/70; A61K31/70
Attorney, Agent or Firm:
Ueki Kuichi