Title:
近位の反応性基を持つポリ(エチレングリコール)誘導体
Document Type and Number:
Japanese Patent JP4078032
Kind Code:
B2
Abstract:
The invention relates to a method for preparing a polymer conjugate, in which a water-soluble polymer employed, the polymer having a linear or branched water-soluble polymer backbone and, at one end of the backbone, a branched moiety linked with two free reactive groups capable of covalent bonding to another molecule. Most specificly, it relates to an activated, substantially water soluble poly(ethylene glycol) having a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reactive groups is reacted with active moieties in a biologically active agent such as a protein or peptide thus forming conjugates between the activated poly(ethylene glycol) and the biologically active agent.
Inventors:
Harris, Jay Milton
Kozlowski, Antoni
Kozlowski, Antoni
Application Number:
JP2000535377A
Publication Date:
April 23, 2008
Filing Date:
March 11, 1999
Export Citation:
Assignee:
Nectar Therapeutics AE, Corporation
International Classes:
C08G65/329; A61K47/48; C08F26/10; C08F216/06; C08G65/32; C08G65/333
Domestic Patent References:
| JP7196925A | ||||
| JP10139877A | ||||
| JP9508926A |
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Arihara Koichi
Matsushima Tetsuo