Title:
オリゴヌクレオチドの送達のための細胞内遊離可能ジスルフィドリンカーを含有するポリマーシステム
Document Type and Number:
Japanese Patent JP2011520983
Kind Code:
A
Abstract:
The present invention provides polymeric prodrugs including an intracellular releasable disulfide linker for the delivery of oligonucleotides. Methods of making the compounds as well as methods of delivering nucleic acids to tumor cells in a mammal using the same are also provided.
Inventors:
Chao Hong
Lady,prasana
Lady,prasana
Application Number:
JP2011510720A
Publication Date:
July 21, 2011
Filing Date:
May 22, 2009
Export Citation:
Assignee:
Enzon Pharmaceuticals, Incorporated
International Classes:
A61K31/7088; A61K47/34; A61K47/48; A61K48/00; A61P35/00
Domestic Patent References:
| JP2006517600A | 2006-07-27 |
Foreign References:
| WO2006069388A2 | 2006-06-29 | |||
| WO2008034123A2 | 2008-03-20 | |||
| WO2008034124A2 | 2008-03-20 |
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka