PREPARATION OF CARBOXAMIDE OF NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND AND ITS USE

Title:

PREPARATION OF CARBOXAMIDE OF NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND AND ITS USE

Document Type and Number:

Japanese Patent JP3493727

Kind Code:

B2

Abstract:

PURPOSE: To provide a new method for preparing the carboxamide of nitrogen- containing heterocyclic compound(N-heterocyclic compound) useful as an important intermediate for producing pharmaceuticals, which can be employed on an industrial scale.
CONSTITUTION: The objective carboxamide of N-heterocyclic compound is obtained by reacting a N-heterocyclic compound with 3-35 moles, preferably 5-8 moles of formamide per mole of the N-heteroeyclic compound, in the presence of 1.1-3.0 moles of oxodisulfuric acid or its salt(preferably, ammonium salt) per mole of the N-heterocyclic compound at 20-80°C, preferably 65-75°C. It is preferable to carry out the reaction mentioned above in the presence of a strong acid in order to improve the selectivity in the carbamoylation. The carboxamide thus obtained is easily converted into a carboxylic acid of N- heterocyclic compound by hydrolysis.

Inventors:

Jean-Paul Rodui
Alan Werich
Karin Amacker
Martin Ayer

Application Number:

JP11656294A

Publication Date:

February 03, 2004

Filing Date:

May 30, 1994

Export Citation:

Click for automatic bibliography generation Help

Assignee:

LONZA LIMITED

International Classes:

C07B43/06; C07B61/00; C07D213/79; C07D213/81; C07D213/82; C07D213/84; C07D215/48; C07D215/50; C07D217/26; C07D213/803; C07D237/24; C07D239/28; C07D241/24; (IPC1-7): C07D213/81; C07D213/803; C07D213/82; C07D213/84; C07D215/48; C07D217/26; C07D237/24; C07D239/28; C07D241/24

Domestic Patent References:

JP5432562A

Other References:

【文献】米国特許3781286(US,A)
【文献】米国特許2780624(US,A)

Attorney, Agent or Firm:

Fumio Suga

Previous Patent: LASER BEAM SCANNING DEVICE

Next Patent: AUTOMATIC RESET DEVICE OF PART MOUNTING EQUIPMENT