PURPOSE: To obtain the titled compound without using the cultivation method, by condensing a specific tunicaminyluracil derivative with a glucosamine derivative in the presence of a silver salt, and eliminating protecting groups.
CONSTITUTION: A compound expressed by formula I [R1 is alkanolyoxy or halogen; R2 is alkanoly, alkenoyl, (substituted) alkoxycarbonyl, etc.; R3WR7 are alkanoyl, aroyxl, aralkyl, alkyl, alkenyl, etc.; R3 and R4 and R6 and R7 together constitute acetal or ketal] is condensed with a compound expresed by formula II[R8 is alkanoyl, alkenoyl, (substituted) alkoxycarbonyl, etc.; R9WR11 are alkanoyl, alkenoyl, aralkyl, etc.; R10 and R11 together constitute acetal or ketal] in the presence of a silver salt, e.g. silver carbonate, to give a compound expressed by formula III, and protecting groups are eliminated. A desired acyl group is introduced into the amino group at the 10-position if necessary to give the aimed compound.
SASAI HIROAKI
FUKUDA YOSHIMASA
TAMURA GAKUZO
TAKATSUKI AKIRA
