Title:
活性酸素種スカベンジャー誘導体の調製および使用
Document Type and Number:
Japanese Patent JP7069295
Kind Code:
B2
Abstract:
Compounds of Formula (I)a or (I)b:including certain quinone derivatives, and the corresponding pharmaceutical compositions, which may serve to modulate ferroptosis in a subject. Also disclosed herein are the preparations of these compounds and pharmaceutical compositions and their potential uses in the manufacture of a medicament in reducing reactive oxygen species (ROS) in a cell and for preventing, treating, ameliorating certain related disorder or a disease.
Inventors:
Cyan, dianin
Qi, Zude
Nin, Deschamps
Riu, Chambo
Qi, Zude
Nin, Deschamps
Riu, Chambo
Application Number:
JP2020508480A
Publication Date:
May 17, 2022
Filing Date:
August 17, 2017
Export Citation:
Assignee:
XW Pharma Limited
International Classes:
C07K5/078; A61K38/05; A61K38/06; A61P3/00; A61P9/00; A61P13/00; A61P17/02; A61P21/00; A61P25/00; A61P39/06; A61P41/00; A61P43/00; C07K5/06; C07K5/08
Foreign References:
| US20070161573 | ||||
| US20070161544 |
Other References:
KRAINZ, T. et al.,A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis,ACS Cent. Sci.,2016年,Vol. 2, No. 9,P. 653-659
O'CONNELL, C. E.,Synthesis and evaluation of hydroxyproline-derived isoprenyltransferase inhibitors,Bioorganic & Medicinal Chemistry Letters,1999年,Vol. 9, No. 14,P. 2095-2100,DOI 10.1016/S0960-894X(99)00342-X
O'CONNELL, C. E.,Synthesis and evaluation of hydroxyproline-derived isoprenyltransferase inhibitors,Bioorganic & Medicinal Chemistry Letters,1999年,Vol. 9, No. 14,P. 2095-2100,DOI 10.1016/S0960-894X(99)00342-X
Attorney, Agent or Firm:
Ryoichi Takaoka
Nao Oda
Akiyo Iwahori
Rena Miyoshi
Kamoto Takahashi
Nao Oda
Akiyo Iwahori
Rena Miyoshi
Kamoto Takahashi
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