Title:
PROCESS FOR RECOVERING STATIN COMPOUND FROM FERMENTATION BROTH
Document Type and Number:
Japanese Patent JP2004350687
Kind Code:
A
Abstract:
To provide an effective process for isolating statin compounds from an aqueous fermentation broth, specifically, a process for purifying pravastatin, compactin and lovastatin at an industrial production scale without requiring separation by chromatography.
The process for isolating and purifying pravastatin or its pharmaceutically permissible salts comprises a step for extracting the pravastatin, by using an organic solvent, from a fermentation broth containing the pravastatin produced by microorganisms, wherein an organic solvent having the formula: CH3CO2R (wherein, R is a 3-4C alkyl) is used in the extraction step.
Inventors:
KERI VILMOS
DEAK LAJOS
FORGACS ILONA
SZABO CSABA
NAGYNE EDIT ARVAI
DEAK LAJOS
FORGACS ILONA
SZABO CSABA
NAGYNE EDIT ARVAI
Application Number:
JP2004206262A
Publication Date:
December 16, 2004
Filing Date:
July 13, 2004
Export Citation:
Assignee:
BIOGAL GYOGYSZERGYAR
International Classes:
C07C67/52; C07C67/58; C07C67/60; C07C69/013; C07C69/03; C07C69/30; C07C69/33; C07D309/30; C12N1/15; C12N15/53; C12P7/42; C12P17/06; (IPC1-7): C12P7/42; C07C67/58; C07C69/03
Attorney, Agent or Firm:
Takashi Ishida
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji
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