PURPOSE: To effectively enhance productivity and reduce production cost by effectively binding a fermentation or reaction process and the successive treat ment process when an amino acid, nucleic acid or its derivative is produced using a microbes.
CONSTITUTION: When an amino acid, nucleic acid or its derivative is produced using a microbe, the amino acid, nucleic acid or its derivative is deposited by accumulating these compounds in a concentration higher than solubility in a fermentation tank or reacting tank (a) and then a culture liquid or reaction liquid containing the resultant crystal is continuously or continually fed to liquid cyclone C by an aseptic pump (b) to treat the liquid and a concentrated crystal solution having 30-90wt.% crystal concentration is recovered on the down-stream side (e). On the one hand, a liquid on upstream side (f) is returned to the culture tank or reaction tank (a) or recovered without returning the liquid and culturing or reaction is continued while newly feeding all or part of a culture medium or reaction liquid to the after tank (a) and the amino acid, nucleic acid or its derivative is collected from a concentrated crystal solution recovered from the downstream side (e).
SATO KAZUHIRO
YOKOYAMA MASATO
TAKENOUCHI TOMOHARU
SEKI MITSUYOSHI
IGARASHI KOJI
KISHINO MITSUHIRO
