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Title:
PRODUCTION OF BETA-AMINOALKANOIC ACID DERIVATIVE
Document Type and Number:
Japanese Patent JPH03291259
Kind Code:
A
Abstract:

PURPOSE: To readily obtain the title compound containing a new compound useful as an intermediate for production of carbapenem based antibiotic used in a medicine in good yield by reacting a specific enolate compound used as a nucleophilic agent with specific nitrones.

CONSTITUTION: An enolate compound expressed by formula I [R1 and R2 are H, (protected) OH or alkyl (substituted by acyl), provided that R1 and R2 are simultaneously H; R3 is OH, amino or mercapto which were substituted; M is (substituted) metal] is reacted with nitrones expressed by formula II [R4 is alkyl, aralkyl or (substituted) alkoxyaryl; R5 and R6 are H, alkyl, aryl, acyl or (protected) hydroxyalkyl or R4 is combined with R5 or R6 to form a (substituted) alkylene chain which may be interrupted by a hetero atom to provide the aimed compound expressed by formula III (when R1 to R6 and M are same compounds as the above-mentioned compounds or R1 is alkyl substituted by OH and when R5 or R6 is acyl, R1 is combined with R5 or R6 to form lactone) which is a new compound.


Inventors:
MURAHASHI SHUNICHI
OTAKE HIROAKI
Application Number:
JP8978390A
Publication Date:
December 20, 1991
Filing Date:
April 03, 1990
Export Citation:
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Assignee:
FUJISAWA PHARMACEUTICAL CO
International Classes:
C07D307/33; C07C227/18; C07C229/06; C07C229/22; C07C239/12; C07C269/04; C07C271/22; C07D207/46; C07D211/22; (IPC1-7): C07C227/18; C07C229/06; C07C229/22; C07C239/12; C07C269/04; C07C271/22; C07D207/46; C07D211/22; C07D307/33
Attorney, Agent or Firm:
Ueki Kuichi



 
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