PURPOSE: To efficiently obtain the compound useful as an intermediate for medicines, agricultural chemicals, etc., in a high yield substantially without causing the environmental pollution by reacting a specific arylthiomethylbenzoic acid compound with a chlorinating agent excluding phosphorous compounds and subsequently subjecting the reaction product to a ring-closing reaction in the presence of a Lewis acid.
CONSTITUTION: A 2-(arylthimethyl) benzoic acid compound of formula I (R is H, 1-4C alkyl, 1-4C alkoxy, C1, Br) is reacted with a chlorinating agent excluding phosphorous compounds, such as thionyl chloride, and the reaction product is subjected to a cyclization reaction in the presence of a Lewis acid such as anhydrous ferric chloride (preferably used in an amount of 0.1-2.0 times moles the amount of the compound of formula I) to obtain the objective compound of formula IV such as 6,11-dihydro-dibenzo[b,e]thiepine-11-one.
ITSUDA HIROSHI
YAMASHITA KAZUYOSHI
NAKANO MASAHITO
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