Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
PRODUCTION OF D,L-ALPHA-TOCOPHEROL
Document Type and Number:
Japanese Patent JP2000143656
Kind Code:
A
Abstract:

To produce the subject compound in high yield without causing corrosive actions, etc., with a catalyst by condensing timethylhydroquinone with isophytol in the presence of a specific amine catalyst in supercritical carbon dioxide or supercritical nitrous oxide.

(A) Trimethylhydroquinone is condensed with (B) isophytol in the presence of (D) bis-(trifluoromethylsulfonyl)amine or a metal salt represented by the formula [Met is boron, magnesium, aluminum or the like; (n) is the corresponding valence of the metal atom Met and 1-4] as a catalyst in (C) supercritical carbon dioxide or supercritical nitrous oxide to thereby produce the objective compound. The molar ratio of the component A to the component B is preferably (0.8:1) to (1.2:1). The amount of the component D used is preferably (1:1,000) to (1:10O) based on the component A or B expressed in terms of molar ratio. The amount of the component C used is preferably (2:1) to (8:1) based on the component A or B expressed in terms of weight ratio.


Inventors:
BONRATH WERNER
WANG SHAONING
Application Number:
JP31928399A
Publication Date:
May 26, 2000
Filing Date:
November 10, 1999
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
HOFFMANN LA ROCHE
International Classes:
C07D311/72; B01J31/02; C07B61/00; C07C403/00; (IPC1-7): C07D311/72; B01J31/02
Attorney, Agent or Firm:
Hajime Tsukuni (1 person outside)