To obtain the subject compound useful as an intermediate for a medicine and an agrochemical in high selectivity in a high yield by reacting an epihalohydrin with an aryl Grignard reagent in the presence of a copper compound.
An epihalohydrin of formula I (X is a halogen) is reacted with an aryl Grignard reagent of formula II (Y is a halogen; R1 and R2 are each H, trifluoromethyl, a 1-8C alkyl or the like or R1 and R2 are mutually bonded to form a ring) in the presence of a copper compound (a monovalent or a bivalent copper compound is indicated and, for example, cuprous chloride, cuprous bromide, cuprous iodide and cuprous cyanide are preferably cited) to give a 1-halogeno-2-hydroxy-3-arylpropane of formula III. The amount of the copper compound used in the reaction is preferably 10-4 to 1, especially 10-2 to 0.2 to the epihalohydrin by the molar ratio.
NARITA MACHIKO
TAKEHARA JUN
ICHIKAWA SHUJI
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