Title:
PRODUCTION OF INDOLINE
Document Type and Number:
Japanese Patent JPH01172373
Kind Code:
A
Abstract:
PURPOSE:To efficiently obtain indoline in high yield, b catalytically hydrogenating indole in the presence of a specific inexpensive readily handleable nickel catalyst capable of being recycled and used for a long period with hardly any deterioration in catalytic activity under specific conditions in a relatively short time. CONSTITUTION:Indole is catalytically hydrogenated in the presence of a nickel catalyst containing dry reduced diatomaceous earth as a carrier in an amount of 1-20wt.% based on the indole, as necessary, using a solvent, such as hexane, at 120-180 deg.C under >=20kg/cm<2>.G pressure of H2 for 1-2hr and the catalyst is then separated by a means, such as decantation or filtration. Distillation, etc., is subsequently carried out to afford the aimed indoline useful as a synthetic raw material for medicines, etc., intermediate compound for agricultural chemicals, etc. The separated catalyst and recovered unreacted indole are recycled for use. The above-mentioned nickel catalyst used is obtained by cooling the substance after dry reduction to replace H2 with CO2 gas and slowly adding air to slightly oxidize and stabilize the surface.
Inventors:
TAKEYA SHOJI
NAKAMURA TAKENORI
MIZOI TOMONAO
NAKAMURA TAKENORI
MIZOI TOMONAO
Application Number:
JP32936887A
Publication Date:
July 07, 1989
Filing Date:
December 25, 1987
Export Citation:
Assignee:
SUMIKIN CHEMICAL
International Classes:
C07D209/08; B01J21/16; B01J23/74; B01J23/755; B01J32/00; (IPC1-7): B01J21/16; B01J23/74; B01J32/00; C07D209/08