Title:
PRODUCTION OF ISOTHIOCYANATE COMPOUND
Document Type and Number:
Japanese Patent JP3688785
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain an isothiocyanate compound having functional groups such as a hydroxyl group in the same molecule and useful as a raw material for synthesizing medicines, agricultural chemicals, etc., and as an antibacterial agent and an antifungal agent.
SOLUTION: An amino compound of the formula: R1-NH2 (R1 is a linear paraffin, an olefin, an alkyne, a cycloparaffin, a cycloolefin, an aromatic ring, a heterogeneous compound, etc.,) is reacted with carbon dioxide in the presence of a base (e.g. NaOH), and the obtained dithiocarbamic acid of the formula (M is H, an alkali metal, ammonium) or its salt is reacted with hydrogen peroxide in a solvent (e.g. THF) at 0-40°C to obtain the isothiocyanate compound of the formula: R1-NCS. The carbon disulfide and the base are used in amounts of 1-10 times equivalents and 0.2-2 times equivalents, respectively, per equivalent of the amino group in the amino compound, and the hydrogen peroxide is used in an amount of ≥1.0 times equivalent per equivalent of the dithiocarbamic acid.
Inventors:
Lee leather
Hirokuni Tajima
Hillman Otani
Hirokuni Tajima
Hillman Otani
Application Number:
JP997596A
Publication Date:
August 31, 2005
Filing Date:
January 24, 1996
Export Citation:
Assignee:
Rengo Co., Ltd.
International Classes:
C07C331/20; C07C331/22; C07C331/26; C07C331/28; C07C331/30; (IPC1-7): C07C331/20; C07C331/22; C07C331/26; C07C331/28; C07C331/30
Domestic Patent References:
| JP52039012B1 |
Foreign References:
| US3111536 |
Attorney, Agent or Firm:
Bunji Kamada
Higashio Masahiro
Torii Kazuhisa
Higashio Masahiro
Torii Kazuhisa
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