PRODUCTION METHOD OF CLAVULANIC ACID - SMITHKLINE BEECHAM PLC

Title:

PRODUCTION METHOD OF CLAVULANIC ACID

Document Type and Number:

Japanese Patent JP2004166714

Kind Code:

A

Abstract:

To provide a new clavulanic acid intermediate by an enzyme reaction and a reaction process in its conversion to clavulanic acid.

An enzyme having amidinohydrolase activity is obtained by centrifugation and ultrasonication of Streptomyces clavuligerus ATCC27064 mycelia usable for a reaction in the conversion process from the intermediate to the clavulanic acid and subsequently by separation of them through ion exchange chromatography.

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Inventors:

BAGGALEY KEITH HOWARD
NICHOLSON NEVILLE HUBERT
ELSON STEPHEN WILLIAM
EDWARDS JEFFREY
EARL ALISON JANE
HOLMS WILLIAM HENRY
MOUSDALE DAVID MICHAEL
BALDWIN JACK EDWARD
SCHOFIELD CHRISTOPHER

Application Number:

JP2004062209A

Publication Date:

June 17, 2004

Filing Date:

March 05, 2004

Export Citation:

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Assignee:

SMITHKLINE BEECHAM PLC

International Classes:

C07C257/14; C07C279/14; C07D205/08; C07D503/00; C12N9/06; C12N15/09; C12N9/14; C12N9/70; C12N9/78; C12N15/00; C12N15/57; C12P17/10; C12P17/18; C12R1/465; (IPC1-7): C12N15/09; C12N9/14

Attorney, Agent or Firm:

Aoyama Aoi
Mitsuo Tanaka

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