Title:
PRODUCTION OF MONOCLONAL ANTIGRAM-NEGATIVE ANTIBODY AND USE THEREOF
Document Type and Number:
Japanese Patent JPH01137993
Kind Code:
A
Abstract:
PURPOSE: To obtain a monoclonal antibody of a mammal directed to a lipid A-core part in an endogenous toxin of various Gram-negative bacteria by using specific complete lipopolysaccharides as an antigen acting on immunization of an immunological competitive cell.
CONSTITUTION: Complete lipopolysaccharides of a Gram-negative bacterium in which a lipid A-core part is extracted are used as an antigen acting on the immunization of an immunological competitive cell. The complete lipopolysaccharides are preferably obtained from bacteria of the strains belonging to the genus Echerichia, Klebsiella, Pseudomonas, Enterobacter, Bacteroides, Serratia or Proteus.
Inventors:
PIEERU SUME
MARIFURANSU SARU
RUNE ZARI
MARIFURANSU SARU
RUNE ZARI
Application Number:
JP28321787A
Publication Date:
May 30, 1989
Filing Date:
November 11, 1987
Export Citation:
Assignee:
ROUSSEL UCLAF
International Classes:
A61K39/395; C07K16/12; C12N5/10; C12N15/02; C12P21/00; C12P21/08; G01N33/569; G01N33/577; A61K38/00; C12R1/91; (IPC1-7): A61K39/395; C07K15/04; C12N5/00; C12N15/00; C12P21/00; G01N33/569; G01N33/577
Attorney, Agent or Firm:
Motohiro Kurauchi (1 outside)