To obtain a powdery composition capable of inhibiting the affection of water, capable of being prepared without deteriorating the activity, having excellent flowability and stability, and useful for medicines, etc. by preliminarily coating a water-repellent powder with an oil and fat and subsequently granulating the coated powder with a water-soluble binder.
This method for producing a powdery composition comprises preliminarily coating a water-repellent powder such as a galenical extract powder with an oil and fat such as palm oil and subsequently granulating the coated powder with a water-soluble binder such as dextrin preferably in an amount of 0.5-50 pts.wt. (per 100 pts.wt. of the water-repellent powder). In the oil and fat-coating process, a particulate fat having a melting point of ≥40°C is preferably subjected to a contact collision with the water-repellent powder to coat the water-repellent powder, or sprayed on the water-repellent powder in a liquid state in a fluidized bed layer to coat the water-repellent powder. The water- repellent powder and the oil and fat are preferably used in a weight ratio of 95/5 to 50/50.
KOJIMA YUKIYA
ABEJIMA TOSHIYUKI
| JPH03277237A | 1991-12-09 | |||
| JPS6410973A | 1989-01-13 | |||
| JPS63164864A | 1988-07-08 | |||
| JPH05186335A | 1993-07-27 | |||
| JPH04297414A | 1992-10-21 | |||
| JPS53145961A | 1978-12-19 |