Title:
PROPENOIC ACID DERIVATIVE
Document Type and Number:
Japanese Patent JP3815691
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new propenoic acid derivative, having antagonistic actions on adenosine A1 and useful as a preventing and a therapeutic agent for renal failure, a diuretic agent, etc.
CONSTITUTION: This propenoic acid derivative is expressed by the formula [ring A is an aromatic ring; X, Y and Z are each 0, S, N or C; R1 is a substitutive alkyl or a substitutive heteroaryl; R2 to R4 are each H, an alkyl, an alkenyl, an alkynyl or W-Q (W is a group derived from an alkyl; Q is an aryl, a cycloalkyl, CN, CH, etc.); R' and R' are each H or an alkyl; R7 and R8 are each H, an alkyl, an alkoxy, a substitutive aryl, a substitutive arylakyl, carboxyalkyl, etc., which may be protected, or together with N to which they are bound, may form a ring; B is 0 or S] or a salt thereof, e.g. (+)-(E)-N-{1-(3- chlorophenyl)-2-(pyridin-2-yl)ethyl}-3-(3-1H-phenyl pyrazol-4-yl)-2-propenamide.
Inventors:
Matsukura Masayuki
Keizo Sato
Naoki Yoneda
Commander Masato
Kazutoshi Miyake
Carpenter Kaji
Naoya Kishi
Yoshida Fusayo
Kenichi Nomoto
Toshiaki Ogawa
Tadanobu Takamura
Koichi Nose
Tomimatsu Mikio
Mizuno Masanori
Shigeto Negi
Shigeru Sawada
Keizo Sato
Naoki Yoneda
Commander Masato
Kazutoshi Miyake
Carpenter Kaji
Naoya Kishi
Yoshida Fusayo
Kenichi Nomoto
Toshiaki Ogawa
Tadanobu Takamura
Koichi Nose
Tomimatsu Mikio
Mizuno Masanori
Shigeto Negi
Shigeru Sawada
Application Number:
JP16594794A
Publication Date:
August 30, 2006
Filing Date:
June 24, 1994
Export Citation:
Assignee:
EISAI CO.,LTD.
International Classes:
C07D231/12; A61K31/41; C07D233/64; A61K31/415; A61K31/4245; A61K31/433; A61K31/44; A61K31/4402; A61K31/4418; A61K31/4427; A61K31/443; A61K31/4433; A61P7/10; A61P9/10; A61P13/02; A61P13/12; A61P15/00; A61P43/00; C07C211/27; C07D209/48; C07D213/38; C07D213/61; C07D233/54; C07D261/08; C07D263/32; C07D271/04; C07D271/08; C07D275/02; C07D277/20; C07D277/30; C07D285/06; C07D285/10; C07D291/04; C07D333/46; C07D339/04; C07D339/06; C07D341/00; C07D401/12; C07D401/14; C07D405/12; C07D405/14; C07D409/04; C07D409/12; C07D409/14; C07D417/12; (IPC1-7): C07D231/12; A61K31/415; A61K31/415; A61K31/44; C07C211/27; C07D209/48; C07D213/38; C07D213/61; C07D233/64; C07D261/08; C07D263/32; C07D271/04; C07D271/08; C07D275/02; C07D277/30; C07D285/06; C07D285/10; C07D291/04; C07D333/46; C07D339/04; C07D339/06; C07D341/00; C07D401/12; C07D401/14; C07D405/12; C07D405/14; C07D409/04; C07D409/12; C07D409/14; C07D417/12
Domestic Patent References:
| JP63201169A |